A compilation of known health effects and associated studies can be found at FluorideAlert.org
Fluoride exposure has been linked to health damage and to the exacerbation of underlying health conditions including: arthritis and joint pain, kidney dysfunction, thyroid dysfunction, endocrine disruption, cardiovascular damage, softening and de-mineralizing of the bones (osteomalacia), increase in bone fractures, skeletal and dental fluorosis, neurotoxicity and cognitive effects, lowered IQ in children, gastrointestinal disorders, calcification of the pineal gland, diabetes and blood glucose regulation problems, cancer, oxidative stress, and male reproductive damage, among others.
It's important to note that there is no conclusive evidence of the universal safety of water fluoridation.
Fluoride accumulates in the body over time. This means that even tiny doses can accumulate and cause health damage over time, especially if people are exposed daily via fluoridated water. People with kidney or liver dysfunction or other detoxification problems are at an increased risk for toxic fluoride accumulation in the body.
People at greater risk of health damage from water fluoridation include:
- fetuses and babies
- children
- people with arthritis, joint problems, or skeletal or dental fluorosis
- people with thyroid dysfunction
- people with chemical sensitivities
- people who have been injured by fluorine-infused pharmaceuticals or have a family history of these types of injuries
- people with ADHD, autism, or other cognitive issues linked to chemical toxicity
- people with cognitive decline
- people with diabetes or blood sugar regulation problems
- people with sensitive kidneys or kidney dysfunction
- people with hindered detoxification
- people with a personal or family history of heart disease
- people with a personal or family history of cancer
This is a sampling of studies and links showing health damage from fluoride exposure:
NEUROTOXICITY, COGNITIVE EFFECTS, AND LOWERED IQ SCORES IN CHILDREN
Link: https://ehp.niehs.nih.gov/doi/10.1289/EHP14534
“Conclusion:
Urinary fluoride concentrations measured prenatally and during childhood (child urinary fluoride concentrations above -0.47 on the log2 scale (corresponding to 0.72 mg/L) were associated with lower cognitive abilities, especially perceptual reasoning and verbal abilities, in Bangladeshi children.”
Link: https://jamanetwork.com/journals/jamapediatrics/fullarticle/2828425
“Findings
Despite differences in exposure and outcome measures and risk of bias across studies, and when using group-level and individual-level exposure estimates, this systematic review and meta-analysis of 74 cross-sectional and prospective cohort studies found significant inverse associations between fluoride exposure and children’s IQ scores.”
Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6–12 Years of Age in Mexico
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915186/
“Conclusions
In this study, higher prenatal fluoride exposure, in the general range
of exposures reported for other general population samples of pregnant women
and nonpregnant adults, was associated with lower scores on tests of cognitive
function in the offspring at age 4 and 6–12 y.”
Neurobehavioural effects of developmental toxicity (autism, ADHD, dyslexia, cognitive impairment)
Link: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(13)70278-3/fulltext
“Conclusions and recommendations
The updated findings presented in this Review confirm and extend our 2006 conclusions. During the 7 years since our previous report, the number of industrial chemicals recognised to be developmental neurotoxicants has doubled. Exposures to these industrial chemicals in the environment contribute to the pandemic of developmental neurotoxicity.
Two major obstacles impede efforts to control the global pandemic of developmental neurotoxicity. These barriers, which we noted in our previous review6 and were recently underlined by the US National Research Council,111 are: large gaps in the testing of chemicals for developmental neurotoxicity, which results in a paucity of systematic data to guide prevention; and the huge amount of proof needed for regulation. Thus, very few chemicals have been regulated as a result of developmental neurotoxicity.
The presumption that new chemicals and technologies are safe until proven otherwise is a fundamental problem.111 Classic examples of new chemicals that were introduced because they conveyed certain benefits, but were later shown to cause great harm, include several neurotoxicants, asbestos, thalidomide, diethylstilboestrol, and the chlorofluorocarbons.112 A recurring theme in each of these cases was that commercial introduction and wide dissemination of the chemicals preceded any systematic effort to assess potential toxicity. Particularly absent were advance efforts to study possible effects on children's health or the potential of exposures in early life to disrupt early development. Similar challenges have been confronted in other public health disasters, such as those caused by tobacco smoking, alcohol use, and refined foods. These problems have been recently termed industrial epidemics.”
Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491930/
“In conclusion, our results support the possibility of adverse effects of fluoride exposures on children’s neurodevelopment.”
Fluoride exposure from infant formula and child IQ in a Canadian birth cohort
Link: https://www.sciencedirect.com/science/article/pii/S0160412019326145?via%3Dihub
“Conclusions
Exposure to increasing levels of fluoride in tap water was associated with diminished non-verbal intellectual abilities; the effect was more pronounced among formula-fed children.”
Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6–12 Years of Age in Mexico
Link: https://ehp.niehs.nih.gov/doi/10.1289/ehp655
“Conclusions:
In this study, higher prenatal fluoride exposure, in the general range of exposures reported for other general population samples of pregnant women and nonpregnant adults, was associated with lower scores on tests of cognitive function in the offspring at age 4 and 6–12 y.”
Association Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offspring in Canada
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704756/
“Conclusions and Relevance
In this study, maternal exposure to higher levels of fluoride during pregnancy was associated with lower IQ scores in children aged 3 to 4 years. These findings indicate the possible need to reduce fluoride intake during pregnancy.”
Neurotoxicity of sodium fluoride in rats
Link: https://pubmed.ncbi.nlm.nih.gov/7760776/
“Fluoride exposures caused sex- and dose-specific behavioral deficits with a common pattern. Males were most sensitive to prenatal day 17-19 exposure, whereas females were more sensitive to weanling and adult exposures. After fluoride ingestion, the severity of the effect on behavior increased directly with plasma F levels and F concentrations in specific brain regions. Such association is important considering that plasma levels in this rat model (0.059 to 0.640 ppm F) are similar to those reported in humans exposed to high levels of fluoride.”
Link: https://pubmed.ncbi.nlm.nih.gov/32865723/
"Excess fluoride intake has been linked with various pathological conditions. The objective of the present study was to understand the role of fluoride in neurotoxic, neuroinflammatory, and neurodegenerative changes in the brain tissue of Wistar rats."
Influence of chronic fluorosis on membrane lipids in rat brain
Link: https://pubmed.ncbi.nlm.nih.gov/9761592/
“The results demonstrate that the contents of phospholipid and ubiquinone are modified in brains affected by chronic fluorosis and these changes of membrane lipids could be involved in the pathogenesis of this disease.”
Link: https://fluoridealert.org/studytracker/?effect=brain-2&sub=cellulartissue-damage&type=animals&start_year=&end_year=&fulltext=&fantranslation=
74 human studies linking fluoride exposure with reduced intelligence
Link: https://fluoridealert.org/studies/brain01/
Link: https://fluoridealert.org/studies/brain02_/
ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)
Link: https://ehjournal.biomedcentral.com/articles/10.1186/s12940-015-0003-1
“Conclusions
Parents reported higher rates of medically-diagnosed ADHD in their children in states in which a greater proportion of people receive fluoridated water from public water supplies. The relationship between fluoride exposure and ADHD warrants future study.”
Link: https://www.sciencedirect.com/science/article/pii/S0160412018311814?via%253Dihub
“Conclusion
Higher levels of fluoride exposure during pregnancy were associated with global measures of ADHD and more symptoms of inattention as measured by the CRS-R in the offspring.”
Link: https://www.sciencedirect.com/science/article/pii/S0160412019315971
“A 1 mg/L increase in tap water fluoride level was associated with a 6.1 times higher odds of an ADHD diagnosis (95% CI = 1.60, 22.8). A significant interaction between age and tap water fluoride level (p = .03) indicated a stronger association between tap water fluoride and hyperactivity/inattention symptoms among older youth. A 1 mg/L increase in water fluoride level was associated with a 1.5 SDQ score increase (95% CI: 0.23, 2.68, p = .02) for youth at the 75th percentile of age (14 years old). Similarly, there was a significant interaction between age and CWF. At the 75th percentile of age (14 years old), those living in a fluoridated region had a 0.7-point higher SDQ score (95% CI = 0.34, 1.06, p < .01) and the predicted odds of an ADHD diagnosis was 2.8 times greater compared with youth in a non-fluoridated region (aOR = 2.84, 95% CI: 1.40, 5.76, p < .01).”
ARTHRITIS, SKELETAL AND DENTAL FLUOROSIS, AND BONE DAMAGE
Fluoride in Drinking Water: A Review on the Status and Stress Effects
Link: https://www.researchgate.net/publication/233357494_Fluoride_in_Drinking_Water_A_Review_on_the_Status_and_Stress_Effects
“[I]ncidence of dental, skeletal and crippling skeletal fluorosis was reported in India with average fluoride concentrations as low as 0.5, 0.7 and 2.8 ppm respectively. Fluorosis, turns out to be the most widespread geochemical disease in India, affecting more than 66 million people including 6 million children under 14 years age. Though fluoride has spread its tentacles in 36,988 habitations and the number of people falling prey to fluoride poisoning have been steadily increasing, an exact exposure-health relationship is yet to be properly elucidated. There is an essential relation between poverty and fluorosis as malnutrition is found to play an aggressive role in its severity.”
Link: https://pubmed.ncbi.nlm.nih.gov/34166938/
“[O]ur study showed that even low level of water or plasma fluoride exposure was associated with increased the risk of dental fluorosis.”
Skeletal fluorosis from brewed tea
Link: https://pubmed.ncbi.nlm.nih.gov/21593111/
“Conclusion:
Our patient shows that [skeletal fluorosis] can result from chronic consumption of large volumes of brewed tea.”
What Is Your Guess? A Case of Thick but Brittle Bones and Instant Tea
Link: https://academic.oup.com/clinchem/article/56/6/1041/5622483
“Given the patient’s history of well-water and instant-tea consumption, radiographic findings, and increased plasma fluoride, the diagnosis of skeletal fluorosis was given. Fluoride sequesters in bone and enhances osteoblast action, thus toxicity leads to dense but brittle bones. The high concentrations of fluoride in instant tea preparations (1) and groundwater contamination with fluoride(2) may both have contributed to this patient’s condition.”
Fluoride-related bone disease associated with habitual tea consumption
Link: https://pubmed.ncbi.nlm.nih.gov/17550752/
“The current cases show that fluoride-related bone disease is an important clinical consideration in patients with dense bones or gastrointestinal symptoms and a history of excessive tea consumption. Furthermore, fluoride excess should be considered in all patients with a history of excessive tea consumption, especially due to its insidious nature and nonspecific clinical presentation.”
Fluoride in Drinking Water, Diet, and Urine in Relation to Bone Mineral Density and Fracture Incidence in Postmenopausal Women Link: https://ehp.niehs.nih.gov/doi/10.1289/EHP7404 "Conclusion
Link: https://fluoridealert.org/bao-2003/
Link: https://fluoridealert.org/issues/health/arthritis/
INFLAMMATION
Link: https://ehjournal.biomedcentral.com/articles/10.1186/s12940-022-00911-6
"Conclusion: Our finding that neutrophils and monocytes are associated with higher plasma fluoride in U.S. children and adolescents is consistent with animal data showing fluoride related effects of increased inflammation. These findings suggest the importance of further studies to assess potential mechanisms that are involved in absorption and filtration of ingested fluoride, particularly in tissues and organs such as the small intestine, liver and kidney."
REPRODUCTIVE DAMAGE AND INFERTILITY
Link: https://www.semanticscholar.org/paper/Toxic-effects-of-fluoride-on-reproductive-ability-Junling-Yingmei/568e3e54d6d332107090bfafa1eb7dad95056f26
“[Fluoride] exhibits toxic effects on reproductive function in the form of decreased sperm motility, enhanced oxidative stress, and increased apoptosis, although the latter does not appear to be directly connected with the increased level of oxidative stress.”
Link: https://pubmed.ncbi.nlm.nih.gov/32984109/
"Conclusions: Excess fluoride exposures can have deleterious effects on the expecting mother and fetus and is associated with adverse pregnancy outcomes."
In vitro influence of sodium fluoride on ram semen quality and enzyme activities
Link: https://www.semanticscholar.org/paper/In-vitro-influence-of-sodium-fluoride-on-ram-semen-Zakrzewska-Uda%C5%82a/5ec7865f43a1e500e8a798d80b7633f32e9b9be2
“SUMMARY:
The percentage of spermatozoa in ram semen with intact acro- somes and
the level of spermatozoa motility decreased significantly after dilu- tion and
after 5 hr incubation at 38oC. Both indices decreased significantly in the
presence of NaF at concentrations ranging from 20 µmol/L to 0.1 mol/L.”
Link: https://pubmed.ncbi.nlm.nih.gov/35897326/
“Results:
Women with LBW infants were exposed to significantly higher levels of water fluoride compared to those with normal birth weight infants. Our findings suggest a significant association between excess water fluoride exposure (>0.7 ppm) and LBW weight in Hispanic women, independent of established LBW risk factors. In logistic regression models, Hispanic women exposed to increased levels of water fluoride were 1.5 times more likely to give birth to an LBW infant and 3.5 more likely to give birth to a VLBW infant. Conclusion: Taken together, these findings can inform public health education strategies that highlight water fluoride as a potential risk factor during pregnancy in Hispanic women.”
60+ animal studies linking fluoride exposure to male reproductive damage
Link: https://fluoridealert.org/studies/fertility02/
KIDNEY DISEASE AND DYSFUNCTION
Link: https://pubmed.ncbi.nlm.nih.gov/35688217/
"Conclusions: Water fluoridation results in higher plasma fluoride levels in those with lower renal function. How routine water fluoridation may affect the many millions of Americans with Chronic Kidney Disease, who are particularly susceptible to heavy metal and mineral accumulation, needs to be further investigated."Back pain in chronic renal failure
Link: https://academic.oup.com/ndt/article/21/8/2331/1820840
"Main sources of fluoride include food and water. About 50–70% of fluoride is excreted by the kidneys [1]. Individuals with kidney disease have decreased ability to excrete fluoride in urine and are at risk of developing fluorosis even at normal recommended limit of 0.7 to 1.2 mg/l (37–63 µmol/l) of fluoride in drinking water [2]."
Link: https://pubmed.ncbi.nlm.nih.gov/9800387/
“Serum and urine fluoride levels were determined in 250 healthy subjects (15-90 years, 122 men and 128 women) residing in Catalonia, Spain, and in 150 patients (20-81 years, 84 men and 66 women) with chronic renal failure undergoing regular dialysis treatment, living in the same geographical area, to determine normal range and to investigate its relationships to age, sex and renal function…Urine fluoride concentration in the healthy group was 671 +/- 373 micrograms/24 h, ranging from 156 to 1900 micrograms/24 h. Fluoride status in the patient group was significantly greater than the control group. There was significant correlation between serum fluoride and age.”
Link: https://www.researchgate.net/publication/5930763_Fluoridation_of_drinking_water_and_chronic_kidney_disease_Absence_of_evidence_is_not_evidence_of_absence
“The National Kidney Foundation in its ‘Position Paper on Fluoride—1980’ as well as the Kidney Health Australia express concern about fluoride retention in kidney patients. They caution physicians to monitor the fluoride intake of patients with advanced stages of kidney diseases. However, a number of reasons will account for the failure to monitor fluoride intake in patients with stages 4 and 5 of chronic kidney diseases and to detect early effects of fluoride retention on kidneys and bone. The safety margin for exposure to fluoride by renal patients is unknown, measurements of fluoride levels are not routine, the onset of skeletal fluorosis is slow and insidious, clinical symptoms of this skeletal disorder are vague, progression of renal functional decline is multifactorial and physicians are unaware of side effects of fluoride on kidneys or bone.”
Link: https://fluoridealert.org/issues/health/kidney/
Fluoride as a cause of kidney disease in humans
Link: https://fluoridealert.org/studies/kidney07/Kidney damage in fluoride-exposed animals
Link: https://fluoridealert.org/studies/kidney08/
DIABETES AND IMPAIRED GLUCOSE REGULATION
Inhibitory effect of fluoride on insulin receptor autophosphorylation and tyrosine kinase activity.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132568/
“Fluoride is a nucleophilic reagent which has been reported to inhibit a variety of different enzymes such as esterases, asymmetrical hydrolases and phosphatases. In this report, we demonstrate that fluoride inhibits tyrosine kinase activity of insulin receptors partially purified from rat skeletal muscle and human placenta…
These data suggest: (i) that fluoride interacts directly and slowly with the insulin receptor, which causes inhibition of its phosphotransferase activity; (ii) that the binding site of fluoride is not structurally modified by receptor phosphorylation; and (iii) based on the fact that fluoride inhibits phosphotransferase activity in the absence of alterations in the binding of ATP, Mn2+ or insulin, we speculate that fluoride binding might affect the transfer of phosphate from ATP to the tyrosine residues of the beta-subunit of the insulin receptor and to the tyrosine residues of exogenous substrates.”
Link: https://pubmed.ncbi.nlm.nih.gov/8405753/
“Endemic fluorosis is a condition resulting from prolonged ingestion of drinking water which contains excess fluoride. Studies on rats have suggested that fluoride toxicity may produce glucose intolerance and abnormalities in insulin secretion…The present study shows that chronic fluoride toxicity in humans could result in significant abnormalities in glucose tolerance which are reversible upon removal of the excess fluoride.”
Topical fluorides: effects on physiologic and biochemical processes
Link: https://pubmed.ncbi.nlm.nih.gov/3475325/
“The ingestion of fluoride from dentifrices or mouthrinses can contribute substantially to the total daily intake of the ion, even in communities that provide optimally fluoridated drinking water. It is concluded that the frequent and unsupervised use of these products by children six years of age or younger, especially those living in areas with water fluoridation, places them at risk of dental fluorosis.”
Does Fluoridation Affect Diabetes Risk?
Link: https://www.dentalnewspk.com/08-Nov-2022/does-fluoridation-affect-diabetes-risk
"Fluoride has been found to raise blood sugar levels and reduce glucose
tolerance, perhaps by preventing insulin generation or secretion. A dose
of fluoride that can be attained in locations with "optimally"
fluoridated water has been proven to cause impaired glucose tolerance in
humans, which is frequently a precursor to type 2 diabetes. This intake ranges from 0.07 to 0.4 mg/kg/day. Therefore, current fluoride intake may cause or aggravate some types of diabetes."
Fluoride and impaired glucose tolerance
Link: https://fluoridealert.org/studies/diabetes01/
THYROID DYSFUNCTION
Thyroid function, intelligence, and low-moderate fluoride exposure among Chinese school-age children
Link: https://pubmed.ncbi.nlm.nih.gov/31698198/
“Our study suggests low-moderate fluoride exposure is associated with alterations in childhood thyroid function that may modify the association between fluoride and intelligence.”
Link: https://pubmed.ncbi.nlm.nih.gov/7859263/
“An investigation on children's intelligence and the metabolism of iodine and fluorine in high iodine and fluorine regions was carried out. The results were as follows. In high iodine and high fluorine areas, the thyroid enlargement prevalence rate among inhabitants and that among children were 3.8% and 29.8%, respectively…These results indicate that high iodine and high fluorine exert severe damage to human body.”
Link: https://jech.bmj.com/content/69/7/619?sid=387994a1-4d28-493a-bef6-8fdf845ecbb0
“Interpretation
In many areas of the world, hypothyroidism is a major health concern and in addition to other factors—such as iodine deficiency—fluoride exposure should be considered as a contributing factor. The findings of the study raise particular concerns about the validity of community fluoridation as a safe public health measure.”
Link: https://pubmed.ncbi.nlm.nih.gov/25556215/
“Cumulative fluoride exposure has adverse influences on children's intelligence quotient (IQ)… In conclusion, fluoride exposure was adversely associated with children's intelligence, whereas the COMT polymorphism may increase the susceptibility to the deficits in IQ due to fluoride exposure. Moreover, the proteomic analysis can provide certain basis for identifying the early biological markers of fluorosis among children.”
Link: https://pubmed.ncbi.nlm.nih.gov/30316182/
“Conclusions:
Adults living in Canada who have moderate-to-severe iodine deficiencies and higher levels of urinary fluoride may be at an increased risk for underactive thyroid gland activity.”
CARDIOVASCULAR DAMAGE
Drinking water fluoride and blood pressure? An environmental study
Link: https://pubmed.ncbi.nlm.nih.gov/21484404/
“The relationship between intakes of fluoride (F) from drinking water and blood pressure has not yet been reported. We examined the relationship of F in ground water resources (GWRs) of Iran with the blood pressure of Iranian population in an ecologic study…
In conclusion, we found the increase of hypertension prevalence and the [systolic blood pressure] mean with the increase of F level in the GWRs of Iranian population.”
Association of vascular fluoride uptake with vascular calcification and coronary artery disease
Link: https://pubmed.ncbi.nlm.nih.gov/21946616/
“Conclusion:
An increased fluoride uptake in coronary arteries may be associated with an increased cardiovascular risk.”
Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta
Link: https://pubmed.ncbi.nlm.nih.gov/22422340/
“Epidemiological and experimental studies have demonstrated the atherogenic effects of environmental toxicant arsenic and fluoride. Inflammatory mechanism plays an important role in the pathogenesis of atherosclerosis…We showed that inflammatory responses but not lipid metabolic disorder may play a crucial role in the mechanism of the cardiovascular toxicity of arsenic and fluoride.”
Link: https://pubmed.ncbi.nlm.nih.gov/21342861/
“Conclusion:
Endemic fluorosis is a risk factor for decrease in calcium and FT4 levels, increase in sodium levels and QT prolongation. These findings might be related with some cardiovascular system dysfunctions such as arrhythmias or syncope. Subjects with fluorosis should be monitored in terms of long QT and QTc intervals.”
Effects of sodium fluoride on the electrocardiogram of male rabbits
Link: https://www.researchgate.net/publication/235906983_Effects_of_sodium_fluoride_on_the_electrocardiogram_of_male_rabbits
“The results indicate that [fluoride] adversely affects the [electrocardiogram] in male rabbits.”
Link: https://www.researchgate.net/publication/26715181_Alterations_in_Electrocardiographic_Parameters_after_Subacute_Exposure_of_Fluoride_and_Ameliorative_Action_of_Aluminium_Sulphate_in_Goats
“Fluorosis or crippling disease is one of the existing environmental challenges for animal and human beings in most parts of the globe.On the basis of results, it may be concluded that subacute toxicity of fluoride produces significant changes in different waves of electrocardiogram and aluminium sulphate has ameliorative efficacy.”
Effects of chronic fluorosis on electrocardiogram in sheep
Link: https://pubmed.ncbi.nlm.nih.gov/12746571/
“This study was carried out to evaluate the effects of chronic fluorosis by means of the electrocardiograms in sheep. Ten sheep with fluorosis living around a volcanic mountain (Tendürek Mount) in East Anatolia in Turkey and 10 healthy sheep were used. Leads I, II, III, aVR, aVL, aVF, V2, V4, and V10 were recorded in the electrocardiographs of the sheep. All waves were seen in all derivations. The P-Q interval was significantly (p<0.05) prolonged and sinus bradycardia was observed in the sheep with fluorosis. As a result of this, the number of heart beats was decreased significantly (p<0.05); that is, the number of heart beats was 110 +/- 15 in the control group and 75 +/- 10 in sheep with fluorosis.”
Histopathology of myocardial damage in experimental fluorosis in rabbits
Link: https://www.researchgate.net/publication/228361564_Histopathology_of_myocardial_damage_in_experimental_fluorosis_in_rabbits
“Young albino rabbits were administered 5, 10, 20, and 50 mg of so-dium fluoride/kg body weight/day subcutaneously for 3.5 months. The control animals were given 1 mL of double distilled water/kg body weight/day. In the fluoridated rabbits, the myocardium showed cloudy swellings, sarcoplasmic vacuolization, and small hemorrhages followed by fibrous necrosis. The de-generative changes were most pronounced in animals treated with 50 mg of sodium fluoride/kg body weight/day. The myocardium exhibited fibrous ne-crosis, dissolution of nuclei, fibrillolysis, extensive vacuole formation and in-terstitial cells in the connective tissue. The degree of myocardial damage seemed to be directly proportional to the dosage of fluoride administered. In the control animals, the myocardium showed normal structure without any of the changes mentioned above.”
Link: https://pubmed.ncbi.nlm.nih.gov/21976813/
“Results of this study can be taken as an index of cardio-toxicity in rats exposed to water fluoridation. Further, oral supplementation of selenium and vitamin E not only inhibited oxidative stress but also enhanced the activities of antioxidant enzymes. Administration of antioxidants during fluoride exposure significantly overcame cardiac fluoride toxicity and therefore may be a therapeutic strategy for fluorotic victims.”
Link: https://pubmed.ncbi.nlm.nih.gov/35168424/
“To examine the association between fluoride exposure and childhood blood pressure (BP), we used data involving 3260 subjects participating in the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2016. Both plasma and water fluoride concentrations were measured using the ion-specific electrode…This study suggested that fluoride exposure may affect childhood blood pressure.”
Link: https://fluoridealert.org/issues/health/cardio/
LIVER DAMAGE
Link: https://pubs.acs.org/doi/10.1021/acs.jafc.2c03049
"Fluoride-induced liver injury seriously endangers human and animal health and animal food safety, but the underlying mechanism remains unclear. This study aims to explore the mechanism of miRNAs in fluoride-induced hepatic glycolipid metabolism disorders."
GASTROINTESTINAL DISORDERS AND DISTRESS
Fluoride-induced gastric symptoms in human clinical trials
Link: https://fluoridealert.org/studies/gastric01/
PLANT AND SOIL DAMAGE
Link: https://pubmed.ncbi.nlm.nih.gov/35007676/
Higher fluoride levels in soil were associated with reduced plant height and number of leaves, particularly in early growth phases. There was also increased leaf injury, resulting in increased infestations of powdery mildew.
INCREASED LEAD LEVELS IN WATER AND CHILDREN
Effects of fluoridation and disinfection agent combinations on lead leaching from leaded-brass parts
Link: https://www.sciencedirect.com/science/article/abs/pii/S0161813X07001404
"This study concerns effects on water-borne lead from combinations of chlorine (CL) or chloramines (CA) with fluosilicic acid (FSA) or sodium fluoride (NaF). CL is known to corrode brass, releasing lead from plumbing devices...Over the first test week (after CL flushing concentrations were increased from 1.0 to 2.0 ppm) lead concentrations nearly doubled (from about 100 to nearly 200 ppb), but when FSA was also included, lead concentrations spiked to over 900 ppb. Lead concentrations from the CL-based waters appeared to be decreasing over the study period, while for the CA + NH3 + FSA combination, lead concentrations seemed to be increasing with time."
Elevated lead levels have been reported in children who drink fluoridated water. These findings have been repeated in studies on rats:
Link: https://pubmed.ncbi.nlm.nih.gov/20188782/
"Higher blood lead (BPb) levels have been reported in children living in
communities that receive fluoride-treated water. Here, we examined
whether fluoride co-administered with lead increases BPb and lead
concentrations in calcified tissues in Wistar rats exposed to this metal
from the beginning of gestation...These findings show that fluoride consistently increases BPb and
calcified tissues Pb concentrations in animals exposed to low levels of
lead and suggest that a biological effect not yet recognized may
underlie the epidemiological association between increased BPb lead
levels in children living in water-fluoridated communities."
OVERVIEW OF TOXICITY
Fluoride in drinking water: a scientific review of EPA's standards (2006)
Link: https://nap.nationalacademies.org/read/11571/chapter/1
WWA ARTICLE: Jupiter in Pisces and Picking Up the Long, Long Historical Fight Against Fluoride Poisoning
WWA VIDEO: Fluoride/Fluorine Poisoning Through Water and Pharmaceuticals
1 comment:
U.S. federal court has now deemed fluoridation an "unreasonable risk" to the health of children, and the EPA will be forced to regulate it as such.
History has been made. After 7 years of pursuing legal action against the U.S. Environmental Protection Agency (EPA) over the risk posed to the developing brain by the practice of water fluoridation, the United States District Court of the Northern District of California has just ruled on behalf of the Fluoride Action Network and the plaintiffs in our precedent-setting court case. A U.S. federal court has now deemed fluoridation an "unreasonable risk" to the health of children, and the EPA will be forced to regulate it as such. The decision is written very strongly in our favor.
Below is an excerpt from the introduction of the ruling:
"The issue before this Court is whether the Plaintiffs have established by a preponderance of the evidence that the fluoridation of drinking water at levels typical in the United States poses an unreasonable risk of injury to health of the public within the meaning of Amended TSCA. For the reasons set forth below, the Court so finds. Specifically, the Court finds that fluoridation of water at 0.7 milligrams per liter ("mg/L") - the level presently considered "optimal" in the United States - poses an unreasonable risk of reduced IQ in children..the Court finds there is an unreasonable risk of such injury, a risk sufficient to require the EPA to engage with a regulatory response...One thing the EPA cannot do, however, in the face of this Court's finding, is to ignore that risk."
Please stay tuned as we will provide further comprehensive details on the ruling.”
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